Doctors/Physician section

What causes hair loss and baldness?

  • White males suffer the greatest risk of baldness, afflicting 50 percent of those over 40, but blacks, Asians, and women lose their hair too.
  • Hairs become progressively finer, shorter, and lighter over time, called miniaturization, until they become invisible.
  • Powerful male hormones act on follicles that have a genetic predisposition.

Polaris NR-07, 08, 09, and NR-02 Shampoo oppose hormonal damage through numerous complementary pathways, unlike products containing minoxidil alone.

Male pattern baldness afflicts men and women with high levels of testosterone and follicles with genetic predisposition.

Androgenetic alopecia (male pattern baldness) follows a certain pattern for individuals genetically predisposed. The androgen-dependent condition afflicts 50 percent of Caucasian men over 40. For Asian, native American, and African phenotypes, baldness is less severe. Women also suffer.

While the method of pathogenesis is not completely understood, recent clinical experiments allow us to explain many of the steps that lead to hair loss. The affected area undergoes a miniaturization process, during which hair becomes increasingly finer until it is barely visible. Production of pigment also stops and the total number of hair follicles may decrease. While some are lost completely, most hair follicles actually remain present, thus available to be revived by Polaris NR-07.

The strong similarity of fathers to sons does not suggest simple Mendelian inheritance, but rather a polygenic basis. While the predisposing genes are not yet known, those for the 5α-reductase and steroid sulphatase enzymes do not appear to be responsible. Other genes still under study include those for insulin, adrenoleukodystrophy, and steroid metabolism.


Several animals develop hair loss resembling that in humans, including deer, bears, lions, and other primates. One well-studied model is that of the stump-tailed macaque, an Asian monkey, which has helped Polaris to assess the efficacy of several treatments for androgenetic hair loss, including minoxidil, 5α-reductase inhibitors, and androgen receptor blockers. One topical formula available to consumers, Polaris NR-07, contains both minoxidil and 5α-reductase inhibitors, as well as apple polyphenol and several auxiliary agents.


Rodent models are commonly used in scientific experiments on hair loss. The castration of rats results in thicker hair strands and faster entry into anagen growth phase, whereas testosterone supplementation inhibits hair growth. One strain of mouse displays a hominid hair-loss pattern treatable with minoxidil or cyproterone acetate.

Causation >